PUBLICATIONS

(#, co-first author; *, co-corresponding author)

2025

27. Liu S, Ma Q, Zeng C, Li H, Su J, Song Z, Yan R, Zhao Z*, Tian S* , Huang W*. Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications. Biomarker Research , 2025, 13 (1).

26. Wang J, Ma Q, Tian S* . Against Clostridioides difficile Infection: An Update on Vaccine Development. Toxins , 2025, 17 (5).

2024

25. Tian S* , Qin Y, Wu Y, Dong M*. Designing, performing, processing, and validating of a pooled CRISPR perturbation screen for bacterial toxins. Nature Protocols , 2024, 20 (5).

News Reports

2023

24. He A#, Tian S# , Kopper O, Horan DJ, Chen P, Bronson RT, Sheng R, Wu H, Sui L, Zhou K, Tao L, Wu Q, Huang Y, Shen Z, Chen H, He X, Robling AG, Jin R, Clevers H, Xiang D*, Li Z*, Dong M*. Targeted inhibition of Wnt signaling with a bacterial toxin fragment suppresses breast cancer tumor-initiating/ chemo-resistant cells. PLoS Biology , 2023, 21 (11).

News Reports

23. Tian S* , Zhou N. Gaining New Insights into Fundamental Biological Pathways by Bacterial Toxin-Based Genetic Screens. Bioengineering , 2023, 10 (8).

Before PKU

22. Sanduja P, Schmieder S, Baddal B, Tian S , Velarde J, Lencer W, Dong M, Wessels M. SLO co-opts host cell glycosphingolipids to access cholesterol-rich lipid rafts for enhanced pore formation and cytotoxicity. mBio , 2025, e03777-24

21. Chen B, Basak S, Chen P, Zhang C, Perry K, Tian S , Yu C, Dong M, Huang L, Bowen ME*, Jin R*. Structure and conformational dynamics of Clostridioides difficile toxin A. Life Science Alliance , 2022, 5 (6).

20. Xu Y#, Viswanatha R#, Sitsel O, Roderer D, Zhao H, Ashwood C, Voelker C, Tian S , Raunser S*, Perrimon N*, Dong M*. Genome-wide CRISPR Screens in Drosophila Cells Identify Vsg as a Tc Toxin Receptor. Nature , 2022, 610 (7931).

19. Tian S* , Xiong X, Zeng J, Wang S, Tremblay BJ, Chen P, Chen B, Liu M, Chen P, Sheng K, Zeve D, Qi W, Breault DT, Rodríguez C, Gerhard R, Jin R, Doxey AC*, Dong M*. Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants. Nature Communications , 2022, 13 (1).

18. Tian S#* , Liu Y#, Appleton E, Wang H, Church GM, Dong M*. Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms. Cell Reports , 2022, 38 (10).

News Reports

17. Xiong X#, Tian S# , Yang P#, Lebreton F#, Bao H, Sheng K, Yin L, Chen P, Zhang J, Qi W, Ruan J, Wu H, Chen H, Breault DT, Wu H, Earl AM, Gilmore MS*, Abraham J*, Dong M*. Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell , 2022, 185 (7).

Research Highlight, Nature Reviews Microbiology, 2022

News Reports

16. Kowarschik S, Schöllkopf J, Müller T, Tian S , Knerr J, Bakker H, Rein S, Dong M, Weber S, Grosse R, Schmidt G. Yersinia pseudotuberculosis cytotoxic necrotizing factor interacts with glycosaminoglycans. The FASEB Journal , 2021, 3 5 (7).

15. Chen P#, Zeng J#, Liu Z, Thaker H, Wang S, Tian S , Zhang J, Tao L, Gutierrez CB, Xing L, Gerhard R. Huang L, Dong M*, Jin R*. Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection. Nature Communications , 2021, 12 (1).

14. Shao DD, Straussberg R, Ahmed H, Khan A, Tian S , Hill RS, Smith RS, Majmundar AJ, Ameziane N, Neil JE, Yang E, Tenaiji AA, Jamuar SS, Schlaeger TM, Al-Saffar M, Hovel I, Al-Shamsi A, Basel-Salmon L, Amir AZ, Rento LM, Lim JY, Ganesan I, Shril S, Evrony G, Barkovich AJ, Bauer P, Dong M, Borck G, Beetz C, Al-Gazali L, Eyaid W, Walsh CA. A recurrent, homozygous EMC10 frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features. Genetics in Medicine , 2021, 23 (6).

13. Liu Y, Tia n S, Thaker H, Dong M. Shiga toxins: an update on host factors and biomedical applications. Toxins , 2021, 1 3 (3).

12. Liu Z, Zhang S, Chen P, Tian S , Zeng J, Perry K, Dong M, Jin R. Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B. Science Advances , 2021, 7 (43).

11. Tian S , Liu Y, Wu H, Liu H, Zeng J, Choi MY, Chen H, Gerhard R, Dong M. Genome-wide CRISPR screen identifies semaphorin 6A and 6B as receptors for Paeniclostridium sordellii toxin TcsL. Cell Host & Microbe , 2020, 27 (5).

Research Highlight, Signal Transduction and Targeted Therapy, 2020

News Reports

10. He A*, Ma L, Huang Y, Zhang H, Duan W, Li Z, Fei T, Yuan J, Wu H, Liu L, Bai Y, Dai W, Wang Y, Li H, Sun Y, Wang Y, Wang C, Yuan T, Yang Q, Tian S , Dong M, Sheng R*, Xiang D*. CDKL3 promotes osteosarcoma progression by activating Akt/PKB. Life Science Alliance , 2020, 3 (5).

9. Tao L#, Tian S# , Zhang J#, Liu Z, Robinson L, Miyashita SI, Breault DT, Gerhard R, Whelan S, Dong M. Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nature Microbiology , 2019, 4 (10).

News Reports

8. Tian S# , Wu Q#, Zhou B, Choi MY, Ding B, Yang W, Dong M. Proteomic analysis identifies membrane client proteins for the ER membrane protein complex. Cell Reports , 2019, 28 (10).

News Reports

7. Tian S , Siu FM, Lok CN, Fung EYM*, Che CM*. Anticancer aurano fin engages 3-hydroxy-3-methylglutaryl- coenzyme A reductase (HMGCR) as a target. Metallomics , 2019, 11 (11).

6. Tian S , Muneeruddin K, Choi MY, Tao L, Bhuiyan RH, Ohmi Y, Furukawa K, Furukawa K, Boland S, Shaffer SA, Adams RM, Dong M. Genome-wide CRISPR screens for Shiga toxins and Ricin reveal Golgi proteins critical for glycosylation. PLoS Biology , 2018, 16 (11).

News Reports

Our figure was cited by Wikipedia, term "Functional Genomics"

5. Lin J, Wang N, Li Y, Liu Z, Tian S , Zhao L, Zheng Y, Liu S, Li S, Jin C, Xia B. LEC-BiFC: a new method for rapid assay of protein interaction. Biotechnic & Histochemistry , 2011, 86 (4).

4. Tian S , Siu FM, Kui SC, Lok CN, Che CM. Anticancer gold(I)-phosphine complexes as potent autophagy inducing agents. Chemical Communications , 2011, 47 (33).

3. Tian S# , Lin J#, Zhou J, Wang X, Li Y, Ren X, Yu W, Zhong W, Xiao J, Sheng F, Chen Y, Jin C, Li S, Zheng Z*, Xia B*. Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18. Autophagy , 2010, 6 (8).

2. Gordon BR#, Li Y#, Wang L, Sintsova A, van Bakel H, Tian S , Navarre WW, Xia B*, Liu J*. Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis. PNAS , 2010, 107 (43).

1. Lin J, Zheng Z, Li Y, Yu W, Zhong W, Tian S , Zhao F, Ren X, Xiao J, Wang N, Liu S, Wang L, Sheng F, Chen Y, Jin C, Li S, Xia B. A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells. Autophagy , 2009, 5 (3).